Tea's Health Protecting Effects

Cultivated and used as a medicinal plant for thousands of years, tea is undoubtedly one of China’s most important contributions to global civilization. Whether green tea brewed from fresh-picked leaves, or black and oblong teas made from the dried, fermented leaves of the perennial shrub Camellia sinensis, tea is second only to water as the world’s most popular beverage.
Only recently have scientists seriously endeavored to unravel tea’s chemical secrets. This research confirmed what folk healers have believed for centuries. Tea both calms and invigorates, while protecting against various ailments and even contributing to a longer, healthier life.
Tea contains a unique blend of chemicals with a variety of health-enhancing properties. Catechin polyphenols, for instance, are potent antioxidant and anti-inflammatory compounds. The best known of these is epigallocatechin-3 gallate (ECGC), a chemical credited with benefits ranging from fighting cancer to promoting fat and weight loss. Ingested or topically applied green tea polyphenols are even credited with protecting the skin from ultraviolet radiation-induced skin damage.
In addition to ECGC, green tea contains other compounds with equally beneficial bioactive properties. One lesser known but no less important of these compounds is an amino acid called theanine.
Theanine is found almost exclusively in the leaves of Camellia sinensis, a relatively rarity in the plant kingdom, where chemical redundancy is the norm. Theanine accounts for up to 50% of the dry protein weight of green tea. Of course, tea also contains caffeine, a familiar stimulant. Theanine is credited with counterbalancing caffeine’s stimulating effect by inducing relaxation. I finish off each night with a cup of tea and an English muffin for their combined effect of relaxing the mind and body. The precise mechanism by which theanine produces this anxiety-reducing effect remains uncertain, though theanine is known to alter levels of two important mood-regulating neurotransmitters, dopamine and serotonin. Theanine is an Amino Acid from tea and has numerous health-protecting effects.
Researchers in Australia recently compared theanine to alprazolam (Xanax), a standard medication used to treat anxiety. The found that theanine tended to reduce anxiety during a relaxation phase of the study, while the drug had no such effect. Neither substance significantly reduced feelings of anxiousness during a phase of the experiment in which anxiety was induced experimentally.
In an earlier study, scientists used brain-wave monitoring (electroencephalograph, or EEG) to determine the lowest dose at which caffeine stimulated laboratory rats. They then administered theanine directly into the rats bloodstream at a similar dose and noted the theanine counteracted caffeine’s stimulatory effect on the brain. Interestingly, when theanine was given by itself at similar doses—at less than half the "calming" dose—it had a stimulatory effect. The researchers concluded that theanine may have two different effects, stimulating or relaxing, depending on the dose.
Theanine has also been shown to reduce high blood pressure, further evidence that it induces relaxation. Japanese researchers for instance, have demonstrated that theanine reduces blood pressure in a dose-dependent manner in rats serving as a model for human hypertension (elevated blood pressure). The larger the dose of theanine given the rats, the mor dramatic was the reduction in their blood pressure. Intriguingly, when control rats with normal blood pressure were given the highest dose of theanine, they experienced no change in blood pressure. It appears that theanine has no effect of lowering blood pressure in normal individuals, but instead affects blood pressure only when a problem already exists.
Theanine has been shown to prevent lipid peroxidation of LDL (low-density lipoprotein), a protective effect that also undoubtedly contributes to tea’s reputation for promoting cardiovascular health. Peroxidation of lipids is thought to play a role in the development of degenerative conditions such as atherosclerosis. Indeed, theanine appears to exert a variety of complementary beneficial effects.
Japanese researchers experimented on rats with elevated lipid and triglyceride levels cause by liver tumors. After adding powdered green tea and theanine to the rats’ diet, the scientists concluded that theanine was at least partially responsible for suppressing tumors and lowering cholesterol and triglyceride levels. While the blood lipid changes may have resulted solely from the decrease in tumor mass, the scientists speculated that both tea and theanine exert anti-cancer as well as lipid-lowering effects.
Theanine has been demonstrated to cross the blood-brain barrier. In an epidemiological study of nearly 6,000 women living in Japan, those who consumed five or more cups of green tea a day were significantly less likely than non-tea drinkers to suffer stroke. In a follow-up to the study researchers determined that women who routinely drank little or no green tea were more than twice as likely as heavy tea drinkers to suffer stroke or cerebral hemorrhage.
Subsequent experiments have confirmed that the theanine protects the brain from damage during ischemia, a condition in which the brain temporarily receives too little oxygen due to reduced blood flow, which may result from stroke. A recent Japanese study showed that theanine significantly protect the brain after an ischemic incident occurs. Using a rodent model of cerebral arterial blockage, researchers injected theanine immediately before or immediately before and three hours after blood flow to an area of the rodent’s brains was interrupted. Theanine significantly decreased the amount of tissue damaged by the temporary lack of blood. The scientists concluded that theanine provided direct nerve cell protection and suggested that theanine "may be clinically useful for preventing cerebral infarction."
The multi functional molecule theanine has been shown to have anti-cancer effects, by making cancer-killing drugs more efficient while reducing toxicity to normal cells. When co-administered with three common chemotherapeutic agents—doxorubicin, idarubicin, and pirarubicin—theanine prevents cancerous cells from ejecting the drugs after the drugs have entered the tumor cells. The result is increased chemotherapy effectiveness and decreased toxicity to healthy tissues.
Harvard researchers provided scientific evidence to support the long belief that tea enhances immunity in a report published in 2003 in the Proceedings of the National Academy of Sciences. According to scientific evidence, tea acts to prime the immune system to recognize bacterial, fungal and parasitic invaders. It accomplishes this amazing feat, they revealed, by acting as a sort of natural vaccine that teaches immune system cells to recognize certain markers that are commonly present on the surfaces of tumor cells and invading pathogenic organisms.
Tea contains antigens—structures known as nonpeptide alkylamines—that are capable of eliciting an immune system response.
Blood tests showed that tea drinkers, but not coffee drinkers, saw increased production of an important disease-fighting cytokine by their T cells. When pathogens invade, their surfaces often bristle with alkylamines similar to those found in tea. T cells that have been primed by prior exposure to theanine are better equipped to promptly recognize and neutralize the microbial threat. The Harvard researchers concluded, "These data provide evidence that dietary intake of tea . . . containing alkylamine antigens or their precursors (for example theanine) may prime human (gamma) (delta) T cells that then can provide natural resistance to microbial infections and perhaps tumors."

Lowering your risk of ovarian cancer may be as simple as drinking a few cups of tea. Recent research reports that a group of Swedish women who drank at least two cups of tea a day had 46 percent less risk of developing this cancer than those who drank no tea. Interestingly, most of the tea consumed was black.
While it is possible to ingest enough green tea daily to consume therapeutic doses of theanine, it may be more convenient to reap the benefits of this natural health enhancer by taking supplemental theanine in capsule form. Many health care practitioners suggest 200 mg taken twice daily for optimal health benefits.
The above information is available and documented in LIFE EXTENSION’s August 2005 article on "THEANINE An Amino Acid from Tea Has Numerous Health-Protecting Effects."